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1996-02-27
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Document 0435
DOCN M9630435
TI Persistent generalized lymphadenopathy and non-Hodgkin's lymphoma in
AIDS: association with Rochalimaea henselae infection.
DT 9603
AU Peter JB; Boyle M; Patnaik M; Hadfield TL; Barka NE; Schwartzman WA;
Penny RS; Specialty Laboratories, Inc., Santa Monica, California 90404,;
USA.
SO Clin Diagn Lab Immunol. 1994 Jan;1(1):115-6. Unique Identifier :
AIDSLINE MED/96050790
AB Cat scratch disease, which is caused by infection with Rochalimaea
henselae, is often manifested as lymphadenopathy. R. henselae has also
been isolated from human immunodeficiency virus (HIV)-positive patients
with bacillary angiomatosis. In order to determine the frequency of R.
henselae-reactive antibodies in HIV-positive patients with persistent
generalized lymphadenopathy (PGL) or non-Hodgkin's lymphoma (NHL), we
tested a total of 124 HIV-positive patients for R. henselae-reactive
immunoglobulin G (IgG), IgM, and IgA antibodies by an enzyme immunoassay
procedure using whole R. henselae antigen. Of the patients, 7 had PGL,
17 had NHL, and 100 were HIV stage IV (Centers for Disease Control
criteria). A total of 86% of PGL patients (6 of 7) were positive for R.
henselae antibodies (three were positive for IgG, IgA, and IgM, one was
positive for IgG and IgA only, and two were positive for IgG only). A
total of 29% of NHL patients (5 of 17) were positive for R. henselae
antibodies (two were positive for IgG, IgA, and IgM and three were
positive for IgG only). Only 5% of HIV Stage IV patients without
adenopathy (5 of 100) were positive for R. henselae-reactive IgG, IgA,
and IgM. The high prevalence of R. henselae-reactive antibodies in
HIV-positive PGL and NHL patients suggests that R. henselae is a
potential etiologic agent or cofactor in these patients.
DE Angiomatosis, Bacillary/IMMUNOLOGY Antibodies, Bacterial/BLOOD
AIDS-Related Complex/*IMMUNOLOGY Bartonella henselae/*IMMUNOLOGY
Cat-Scratch Disease/*IMMUNOLOGY Human Lymphoma,
Non-Hodgkin's/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).